heeft te maken met serotonine die op plaatsen komt waar het niet hoort te zijn, jah ik heb er ervaring mee het is heel lekker maar zoals de engelse zeggen "morrish" je blijft er van nemen het duurt maar een uurtje of twee, en dan neem je weer en weer
maar de toxicity is wel laag je kunt vrij veel nemen
ik heb t nooit via de neus genomen, zal je met 50 mg wel genoeg hebben dan
maar dit moet je gewoon oraal nemen op een nuchtere maag
zou beginnen met 70 mg ofzo
je hart kan er flink van te keer gaan
je kunt die kerel ook emailen voor methylone alsie nog heeft
het is sinds kort verboden in denemarken maar hij mag zijn "stock nog verkopen"
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Our current methylone prices are:
10g: 300€ (EUR)
20g: 560€ (EUR)
50g: 1000€ (EUR)
100g: 1500€ (EUR)
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deze ken je al?
http://www.mephedrone.com/experiences/
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4-methylmethcathinone
Legal: Under Australian law, in most states 4-Methylmethcathinone can be considered an analogue of the scheduled (illicit) drug methcathinone.
Pharmacological: 4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1)
Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2)
Quote:
Compared with controls, abstinent methamphetamine
and methcathinone users had significant decreases in
DAT density in the caudate nucleus (223 and 224%, respectively)
and putamen (225 and 216%, respectively).
It can be speculated that the para substituted compound 4-methylmethcathinone may have reduced stimulant activity, but as said, its likely to have additional affect on serotonin via both monoamine reuptake/ SERT inhibition and direct agonist affects of the 5HT2b receptors. Concerns have been raised regarding the actions of 4-methylmethcathinone in relation to peripheral 5HT (serotonin) stimulation and how that, combined with other catecholamine activity, may be dangerous to the heart.
In a similar manner to which pulmonary hypertension is caused by peripheral 5HT produced by gastrointestinal carcinoid tumours (and some argue 5HTP), other 5HT2b agonists have been found to cause this effect, which would be exacerbated by increased DA/NE levels and their corresponding affect on the heart. Longer term, such stimulation has been shown to result in fibroblast mitosis of the mitral valve of the left atrium (specifically the Chordae Tendineae). (3,4)
While it has yet to be demonstrated by means of scientific study that 4-methylmethcathinone produces these effects, I believe it's wise to consider carefully the possible toxicity of this compound if you're intending to ingest or otherwise consume products containing this drug.
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