Hey mense,hoe ist nou?
Ik heb laatst na 8 jr. weer 2cb genomen,en ik moet zeggen
errug vet!!!!
Ik heb laatst na 8 jr. weer 2cb genomen,en ik moet zeggen
errug vet!!!!
Forumonderwerp · 800487
59 volgers · 442985x bekeken
Verdikkie ik wil ook 
!
!
Ik zal jullie zo n mailtje sturen 
Ik wil het in mn volgende vakantie en van de zomer doen 
Wil het eigenlijk al jaren doen maar kwam altijd iets tussen. Lijkt me een prettige manier van trippen.
Wil het eigenlijk al jaren doen maar kwam altijd iets tussen. Lijkt me een prettige manier van trippen. Ik wil het in mn volgende vakantie en van de zomer doen Wil het eigenlijk al jaren doen maar kwam altijd iets tussen. Lijkt me een prettige manier van trippen.
Kijk ik wil nou niet zeggen dat ik de man ben van drugs ofzo, maar heb vrijwel alle tripmiddellen die ik ken (sowieso vrijwel alle drugs die ik ken) echt vrij intensief gebruikt.
En naast DMT en andere 2C varianten vind ik 2CB toch echt DE SHIT.
Maar ik denk dat menig tripper dat wel met mij eens is, het is de meest aangename en toch steeds weer "vernieuwende" manier van trippen als je het mij vraagt.
2CB is ook in tegenstelling tot bijvoorbeeld LSD erg goed te sturen, ik kan er bewust voor kiezen een soort trip te nemen op 2CB.
Op alle van je zintuigen kan je trippen met 2CB, op je smaak, je gehoor, je zicht, je tastzin.. name it
C10H14BrO2 laatste aanpassing
Ik wil het nog wel eens nuchter proberen eigenlijk. Met oud en nieuw gehad, maar in combinatie met veel andere shit dus kan de effecten en belevingen niet precies gescheiden houden.
lsd pas veel beter in een envelop 
Binnenkort maar eens 2cb gebruiken.
Ik snap het niet waarom mensen zeggen dat ze geen 2cb kunnen krijgen.
Wie zoekt zal vinden.
Wie zoekt zal vinden.
Receptje nodig?
Veel plezier ermee!
2C-B synthesis without LAH
by Beaker
--------------------------------------------------------------------------------
Introduction
The following is a synthesis of 2C-B from 2,5-dimethoxybenzaldehyde that does not require the use of the slightly hazardous and/or difficult to obtain reagents normally associated with its synthesis, notably LAH, pressurized H2, and Br2. No doubt some clandestine chemists have been discouraged from attempting the synthesis of what is, IMHO, a pretty cool substance by the nature of these reagents and the lack of a clearly written procedure for an alternate route that does not use them. However, alternate routes do exist, and one of them is detailed below. Note that this route does require one additional step to acheive the nitrostyrene reduction than with the use of H2 or LAH, but that the yield is actually substantially higher than what others have reported with those reducing systems. Also, the bromination procedure is somewhat unrefined at present and does not result in the greatest of yields or the easiest of workups, so feel free to use the classical procedure if you want to make or buy your own bromine. As a final note, although this route will happily accomodate batch sizes of ~50g in 2L glassware, it does not scale anywhere near as well as catalytic hydrogenation, so if you're trying to go huge, it's probably not for you.
Procedure
Step 1: Condensation of 2,5-dimethoxybenzaldehyde with nitromethane
In a 500mL RBF equipped with a reflux condenser and a stir bar, place 100g 2,5-dimethoxybenzaldehyde, 15g ammonium acetate, and 250mL of nitromethane. Heat to a gentle reflux while magnetically stirring. Maintain reflux for ~45min, by which time the color of the solution should progress from clear/yellow to a deep reddish-black. Remove heat and carefully pour the hot rxn mixture into 1L of ice-cold 70% IPA. Allow the IPA/rxn mixture to stand for a while. You should now have a flask full of orange solids floating in red/black mother liquor. Vacuum-filter the solids and wash them with additional portions of ice-cold 70% IPA until the filtrate is no longer reddish. Thoroughly dry the collected orange solids by pulling air through the filter for a while and then under vaccum. It is very important that the nitrostyrene be completely dry before proceding to the next step.
Yield - 106.1g (84%) of 2,5-dimethoxynitrostyrene
Purity - Single spot by TLC, NMR is clean
Step 2: Sodium borohydride reduction of 2,5-dimethoxynitrostyrene
Into a dry 2L RBF flask equipped with a stir bar was added 400mL of anhydrous ethanol (If you can't get anhydrous ethanol, use anhydrous IPA (Do not use methanol!!!). The rxn was cooled to 0°C in an ice/water bath and 36.2g of sodium borohydride was added (slight H2 evolution). A pressure-equalized addition funnel was charged with a pre-made saturated solution of 50g 2,5-dimethoxynitrostyrene in THF (about 600mL) and attached to the flask. A piece of tubing was attached to the top of the addition funnel and run outside to vent the hydrogen that is will evolve during the course of the reaction. While maintaining the ice/water bath, slowly (reaction is exothermic, so go slowly) all of the bright yellow nitrostyrene solution (refill the addition funnel if necessary) was added to the sodium borohydride solution over the course of ~90 min (Note: gas will evolve over the course of the addition. It is H2. Be careful). After the addition is complete, the rxn was allowed to stir for an additional 10 min and then poured into a 4L erlenmeyer containing 1L of H2O and a 3" stir bar (H2 evolution). While stirring, 250mL glacial acetic acid (Heavy H2 evolution) was carefully added (one could use 400 mL 31.45% HCl). The quenched reaction mixture was divided into three portions. In a 2L sep funnel, each portion was combined with 500mL Et2O (or toluene) and 500mL brine. The funnel was shaken and the aqueous (bottom) layer was discarded. The organics were washed with 3 additional 500mL portions of brine. This was repeated with the other two portions. The organics were combined, dried over MgSO4, filtered and the solvent evaporated to give a clear yellow oil.
Yield - 47.0g of crude 2,5-dimethoxynitroethane
Purity - Two spots by TLC. NMR analysis indicates a 50:1 molar ratio of the desired product to dimeric impurity (this is the only impurity present). Adjusted yield of 2,5-dimethoxynitroethane is 45.2g (89.5%).
Step 3: Catalytic Transfer Hydrogenation of Crude 2,5-dimethoxynitroethane
The crude product of the previous step was dissolved in 400mL MeOH and placed in a 1L RBF equipped with a stir bar. In a separate beaker away from all combustible materials, 1g of 10% Pd/C was carefully wetted down with MeOH and the resulting slurry transferred to the rxn flask. To the rxn flask was added 62g ammonium formate. The flask was equipped with a reflux condensor, a piece of tubing was attached to the top of the condensor, and the end of the tubing was submenged in a container of water (this works to exclude O2 from the rxn while allowing the evolving CO2 to escape). The rxn was gently refluxed for 24 h (CO2 evolution), cooled, filtered through celite to remove the Pd/C, and the solvent evaporated. The residue was taken up in 150 mL of Et2O (or toluene) and 300 mL of H2O and the pH adjusted to >12 with 20% NaOH. The mixture was transfered to a sep funnel, shaken, and separated. The aqueous layer was extracted with 2x100 mL portions of Et2O (or toluene). The combined organics were dried over MgSO4, filtered, and gassed with HCl (2C-H*HCl is partially soluble in DCM, so don't gas in that solvent). The resulting white crystalline solids were filtered, washed with Et2O, and allowed to air dry to give 2C-H Hydrochloride.
Yield - 43.8g (94%) of 2C-H Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Step 4: Bromination of 2C-H Freebase
The 2C-H*HCl was dissolved in a 300 mL H20. The pH was adjusted to >12 with 20% NaOH and the aqueous layer was extracted with 4x100 mL DCM. The DCM was evaporated to give 2C-H freebase, which was dissolved in 500 mL of 3:1 AcOH/H2O. The rxn was cooled to 0C in an ice/water bath. 37.3g of 48% aq. HBr was added, followed immediately by 23.8g of 30% H2O2. The rxn was stirred for 6 hr, allowing the ice bath to melt. The majority of the AcOH was removed under vacuum and the nasty reddish-black rxn mixture was partitioned between 1L H20 and 500 mL EtOAc (EtOAc was found to be much better for dissolving the impurities in this rxn than Et2O or toluene. This is messy at first, but everything should go into solution after much agitation). The layers were separated and the aqueous extracted with an additional 500 mL EtOAc. The aqueous was basified to pH >12 with 20% NaOH and extracted with 3x200 mL portions of Et2O. The combined organics were washed with 400 mL brine, dried over MgSO4, filtered and gassed with HCl. The resulting tan crystalline solids were filtered and recrystalized from boiling 1:1 IPA/Toluene to give pure 2C-B*HCl as a white crystaline solid.
Yield - 34.0g (57%) of 2C-B Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Before some jackass reads this procedure and asks me why 4 equivalents of sodium borohydride is used for the reduction, here is a interesting little table for your reading pleasure.
Eq. NaBH4 Molar ratio of 2,5-dimethoxy-
phenylnitroethane to dimer
2.5 6.25 : 1
3.5 44 : 1
4.0 50 : 1
--------------------------------------------------------------------------------
Sunlight's Voice:
After several failures, we finally got an interesting success using Beaker's 2C-H synth. We post it due me and others had problems with it. The rxn was carried out exactly as Beaker posted, no problems, everything goes fine. We made the sulfate salt instead of the hydrochloride by adding a 1:10 H2SO4:IPA v/v to the toluene extracts until the pH was slightly acidic. Yield was 65% from the nitrostyrene, not the >80% of Beaker, but anyway really interesting. By the way, we have never got a 84% of the nitro in step one, only 65-75% and reacting 2.5 hours, not 45 minutes, at 45 minutes the rxn seemed to be incomplete.
The reason of the success is the catalyst, all attempts with homemade catalyst gave miniscule yields, so we decided to buy it from Aldrich, 10% Pd/C on activated carbon, and now rxn finally works. In the reduction with Pd/C and ammonium formate, solid crystals are formed in the condenser (we guess they are ammonium carbonate) and they can clog the condenser. We had a little hazard in a previous test, so you need to control it and remove the crystals. We doubled the catalyst in order to finish rxn in 12 hours instead of 24, but rxn finish in about 5 hours, but we let it 12 hours. Other thing, the catalyst was washed with methanol, and when it was drying, it catched fire, next time we'll make a final wash with water before letting it dry, so we could reuse it.
--------------------------------------------------------------------------------
Barium's Voice:
For better yields:
10g (47,4mmol) 1-(2,5-dimethoxyphenyl)-2-nitroethane was dissolved in 50ml EtOH containing 300mg 5% Pd/C in a 250ml rb flask. 14g (166mmol) potassium formate was dissolved in 9ml water (500mmol, roughly 3 eq) and this solution was added to the alcohol solution in one portion. The mixture was heated to 70-75deg C for 5 hours with good stirring. During this time the mixture became thicker and thicker due to the precipitation of KHCO3. After three hours the mixture was too thick to be properly stirred so another 50ml EtOH was added. When 5 hours had passed the the reaction mixture was cooled to roomtemp and acidified to pH2 with dilute HCL , celite added and the catalyst removed by filtration. 100ml water was added to the filtrate and then it was extracted with 2x100ml toluene. The aqueous phase was the basified to pH 12 with 50% aq. NaOH and extracted with 2x100ml toluene. The organic phase was dried with MgSO4 and removed in a rotovap leaving a yellow oil. This oil was dissolved in 100ml EtOAc and gassed with dry HCL. Yield 6,6g (30,3mmol, 64%) 2,5-dimethoxyphenylethylamine HCl, mp 139-140°C.
In the presence of a catalyst hydrogen is formed according to: HCO2K + H2O __> H2 + KHCO3
For further reading check US patent 4,792,625
Veel plezier ermee!
2C-B synthesis without LAH
by Beaker
--------------------------------------------------------------------------------
Introduction
The following is a synthesis of 2C-B from 2,5-dimethoxybenzaldehyde that does not require the use of the slightly hazardous and/or difficult to obtain reagents normally associated with its synthesis, notably LAH, pressurized H2, and Br2. No doubt some clandestine chemists have been discouraged from attempting the synthesis of what is, IMHO, a pretty cool substance by the nature of these reagents and the lack of a clearly written procedure for an alternate route that does not use them. However, alternate routes do exist, and one of them is detailed below. Note that this route does require one additional step to acheive the nitrostyrene reduction than with the use of H2 or LAH, but that the yield is actually substantially higher than what others have reported with those reducing systems. Also, the bromination procedure is somewhat unrefined at present and does not result in the greatest of yields or the easiest of workups, so feel free to use the classical procedure if you want to make or buy your own bromine. As a final note, although this route will happily accomodate batch sizes of ~50g in 2L glassware, it does not scale anywhere near as well as catalytic hydrogenation, so if you're trying to go huge, it's probably not for you.
Procedure
Step 1: Condensation of 2,5-dimethoxybenzaldehyde with nitromethane
In a 500mL RBF equipped with a reflux condenser and a stir bar, place 100g 2,5-dimethoxybenzaldehyde, 15g ammonium acetate, and 250mL of nitromethane. Heat to a gentle reflux while magnetically stirring. Maintain reflux for ~45min, by which time the color of the solution should progress from clear/yellow to a deep reddish-black. Remove heat and carefully pour the hot rxn mixture into 1L of ice-cold 70% IPA. Allow the IPA/rxn mixture to stand for a while. You should now have a flask full of orange solids floating in red/black mother liquor. Vacuum-filter the solids and wash them with additional portions of ice-cold 70% IPA until the filtrate is no longer reddish. Thoroughly dry the collected orange solids by pulling air through the filter for a while and then under vaccum. It is very important that the nitrostyrene be completely dry before proceding to the next step.
Yield - 106.1g (84%) of 2,5-dimethoxynitrostyrene
Purity - Single spot by TLC, NMR is clean
Step 2: Sodium borohydride reduction of 2,5-dimethoxynitrostyrene
Into a dry 2L RBF flask equipped with a stir bar was added 400mL of anhydrous ethanol (If you can't get anhydrous ethanol, use anhydrous IPA (Do not use methanol!!!). The rxn was cooled to 0°C in an ice/water bath and 36.2g of sodium borohydride was added (slight H2 evolution). A pressure-equalized addition funnel was charged with a pre-made saturated solution of 50g 2,5-dimethoxynitrostyrene in THF (about 600mL) and attached to the flask. A piece of tubing was attached to the top of the addition funnel and run outside to vent the hydrogen that is will evolve during the course of the reaction. While maintaining the ice/water bath, slowly (reaction is exothermic, so go slowly) all of the bright yellow nitrostyrene solution (refill the addition funnel if necessary) was added to the sodium borohydride solution over the course of ~90 min (Note: gas will evolve over the course of the addition. It is H2. Be careful). After the addition is complete, the rxn was allowed to stir for an additional 10 min and then poured into a 4L erlenmeyer containing 1L of H2O and a 3" stir bar (H2 evolution). While stirring, 250mL glacial acetic acid (Heavy H2 evolution) was carefully added (one could use 400 mL 31.45% HCl). The quenched reaction mixture was divided into three portions. In a 2L sep funnel, each portion was combined with 500mL Et2O (or toluene) and 500mL brine. The funnel was shaken and the aqueous (bottom) layer was discarded. The organics were washed with 3 additional 500mL portions of brine. This was repeated with the other two portions. The organics were combined, dried over MgSO4, filtered and the solvent evaporated to give a clear yellow oil.
Yield - 47.0g of crude 2,5-dimethoxynitroethane
Purity - Two spots by TLC. NMR analysis indicates a 50:1 molar ratio of the desired product to dimeric impurity (this is the only impurity present). Adjusted yield of 2,5-dimethoxynitroethane is 45.2g (89.5%).
Step 3: Catalytic Transfer Hydrogenation of Crude 2,5-dimethoxynitroethane
The crude product of the previous step was dissolved in 400mL MeOH and placed in a 1L RBF equipped with a stir bar. In a separate beaker away from all combustible materials, 1g of 10% Pd/C was carefully wetted down with MeOH and the resulting slurry transferred to the rxn flask. To the rxn flask was added 62g ammonium formate. The flask was equipped with a reflux condensor, a piece of tubing was attached to the top of the condensor, and the end of the tubing was submenged in a container of water (this works to exclude O2 from the rxn while allowing the evolving CO2 to escape). The rxn was gently refluxed for 24 h (CO2 evolution), cooled, filtered through celite to remove the Pd/C, and the solvent evaporated. The residue was taken up in 150 mL of Et2O (or toluene) and 300 mL of H2O and the pH adjusted to >12 with 20% NaOH. The mixture was transfered to a sep funnel, shaken, and separated. The aqueous layer was extracted with 2x100 mL portions of Et2O (or toluene). The combined organics were dried over MgSO4, filtered, and gassed with HCl (2C-H*HCl is partially soluble in DCM, so don't gas in that solvent). The resulting white crystalline solids were filtered, washed with Et2O, and allowed to air dry to give 2C-H Hydrochloride.
Yield - 43.8g (94%) of 2C-H Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Step 4: Bromination of 2C-H Freebase
The 2C-H*HCl was dissolved in a 300 mL H20. The pH was adjusted to >12 with 20% NaOH and the aqueous layer was extracted with 4x100 mL DCM. The DCM was evaporated to give 2C-H freebase, which was dissolved in 500 mL of 3:1 AcOH/H2O. The rxn was cooled to 0C in an ice/water bath. 37.3g of 48% aq. HBr was added, followed immediately by 23.8g of 30% H2O2. The rxn was stirred for 6 hr, allowing the ice bath to melt. The majority of the AcOH was removed under vacuum and the nasty reddish-black rxn mixture was partitioned between 1L H20 and 500 mL EtOAc (EtOAc was found to be much better for dissolving the impurities in this rxn than Et2O or toluene. This is messy at first, but everything should go into solution after much agitation). The layers were separated and the aqueous extracted with an additional 500 mL EtOAc. The aqueous was basified to pH >12 with 20% NaOH and extracted with 3x200 mL portions of Et2O. The combined organics were washed with 400 mL brine, dried over MgSO4, filtered and gassed with HCl. The resulting tan crystalline solids were filtered and recrystalized from boiling 1:1 IPA/Toluene to give pure 2C-B*HCl as a white crystaline solid.
Yield - 34.0g (57%) of 2C-B Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Before some jackass reads this procedure and asks me why 4 equivalents of sodium borohydride is used for the reduction, here is a interesting little table for your reading pleasure.
Eq. NaBH4 Molar ratio of 2,5-dimethoxy-
phenylnitroethane to dimer
2.5 6.25 : 1
3.5 44 : 1
4.0 50 : 1
--------------------------------------------------------------------------------
Sunlight's Voice:
After several failures, we finally got an interesting success using Beaker's 2C-H synth. We post it due me and others had problems with it. The rxn was carried out exactly as Beaker posted, no problems, everything goes fine. We made the sulfate salt instead of the hydrochloride by adding a 1:10 H2SO4:IPA v/v to the toluene extracts until the pH was slightly acidic. Yield was 65% from the nitrostyrene, not the >80% of Beaker, but anyway really interesting. By the way, we have never got a 84% of the nitro in step one, only 65-75% and reacting 2.5 hours, not 45 minutes, at 45 minutes the rxn seemed to be incomplete.
The reason of the success is the catalyst, all attempts with homemade catalyst gave miniscule yields, so we decided to buy it from Aldrich, 10% Pd/C on activated carbon, and now rxn finally works. In the reduction with Pd/C and ammonium formate, solid crystals are formed in the condenser (we guess they are ammonium carbonate) and they can clog the condenser. We had a little hazard in a previous test, so you need to control it and remove the crystals. We doubled the catalyst in order to finish rxn in 12 hours instead of 24, but rxn finish in about 5 hours, but we let it 12 hours. Other thing, the catalyst was washed with methanol, and when it was drying, it catched fire, next time we'll make a final wash with water before letting it dry, so we could reuse it.
--------------------------------------------------------------------------------
Barium's Voice:
For better yields:
10g (47,4mmol) 1-(2,5-dimethoxyphenyl)-2-nitroethane was dissolved in 50ml EtOH containing 300mg 5% Pd/C in a 250ml rb flask. 14g (166mmol) potassium formate was dissolved in 9ml water (500mmol, roughly 3 eq) and this solution was added to the alcohol solution in one portion. The mixture was heated to 70-75deg C for 5 hours with good stirring. During this time the mixture became thicker and thicker due to the precipitation of KHCO3. After three hours the mixture was too thick to be properly stirred so another 50ml EtOH was added. When 5 hours had passed the the reaction mixture was cooled to roomtemp and acidified to pH2 with dilute HCL , celite added and the catalyst removed by filtration. 100ml water was added to the filtrate and then it was extracted with 2x100ml toluene. The aqueous phase was the basified to pH 12 with 50% aq. NaOH and extracted with 2x100ml toluene. The organic phase was dried with MgSO4 and removed in a rotovap leaving a yellow oil. This oil was dissolved in 100ml EtOAc and gassed with dry HCL. Yield 6,6g (30,3mmol, 64%) 2,5-dimethoxyphenylethylamine HCl, mp 139-140°C.
In the presence of a catalyst hydrogen is formed according to: HCO2K + H2O __> H2 + KHCO3
For further reading check US patent 4,792,625
whahaha misschien dat ik het op de 2cb wel snap 
K zou het nog wel 's willen proberen, maar heb geen connecties in de buurt 
wat is eigenlijk beetje normale prijs voor 2cb?
ik wet wel dat het SUPPPPPPPPER VAAAAAAAAAAG spul =
Super vette nacht gehad...
Lijkt me ook wel is leuk om te proberen
1 keer en nooit meer die zooi
wat is er fout gegaan ??
Ik weet dat het heerlijk spul kan zijn, maar geloof mij, het kan ook je diepste angsten wakker maken. Ik heb een half jaar in een psychose gezeten door een te heftige 2c-b trip, ongeveer 40 mg gesnoven...
Geloof me, met 2c-b kan je ook zeker entiteiten tegen komen en die zijn niet altijd even aardig. Het is een TE bizzar verhaal om hierzo neer te typen maar moest hier toch ff op reageren.
Verder niets tegen 2c-b ik heb jaren genoten van haar prachtige visuals!
laatste aanpassing
Hey Boriz ik heb je verhaal weleens ergens anders gelezen en het is inderdaad zo'n beetje het ergste wat er kan gebeuren
Wat ik me afvroeg; heb je het toen ook met andere drugs gecombineerd?
Wat ik me afvroeg; heb je het toen ook met andere drugs gecombineerd?
ja dat vraag k me eigenlijk ook af. Hoewel ik het zelf wel vaak combineer met andere drugs en wat bij mij nou niet bepaald een ongewenst effect geeft hehehe 
maar bij snuiven krijg je wel meteen de volle klap. Binnen paar minuten ben je al flink aant space, hoewel dit bij (minder) hoeveelheid wel prettig kan zijn ( t snuiven zelf uiteraard niet ).
maar bij snuiven krijg je wel meteen de volle klap. Binnen paar minuten ben je al flink aant space, hoewel dit bij (minder) hoeveelheid wel prettig kan zijn ( t snuiven zelf uiteraard niet ). Uitspraak van D>U> op maandag 25 februari 2008 om 22:32:
wat is er fout gegaan ??
ahhaha nou de werking is gewoon zo onverwachts en houd heeeeeeel lang aan...ik ben alleen xtc gewend dus mischien vandaar..maar ik had een beetje in een discotheek genomen
pas 4 uur later toen ik thuis was werd ik echt zo wazig en ziek kon me lichaam niet meer onder controle houde heb water gedronken voor leven en 1 keer flink lopen braken en toen ging et wel weer maar je word echt zo duizelig daarvan wil ik nooit meer meemakennn
wat is er fout gegaan ??
ahhaha nou de werking is gewoon zo onverwachts en houd heeeeeeel lang aan...ik ben alleen xtc gewend dus mischien vandaar..maar ik had een beetje in een discotheek genomen
pas 4 uur later toen ik thuis was werd ik echt zo wazig en ziek kon me lichaam niet meer onder controle houde heb water gedronken voor leven en 1 keer flink lopen braken en toen ging et wel weer maar je word echt zo duizelig daarvan wil ik nooit meer meemakennn
binnenkort ook maar eens proberen.. ben benieuwd
ongeveer 40 mg gesnoven...
Dan had je beter moeten lezen vantevoren, dan had je geweten dat als je het snuift het 3 tot 4 keer zo sterk is. Je hebt dus een dosis binnen gekregen die te vergelijken is met 120 tot 160 mg oraal.
de werking is gewoon zo onverwachts en houd heeeeeeel lang aan
Raar, als ik 25 mg neem werkt het na een uurtje volop, en 3 uur daarna is het alweer bijna weg.
Je kan het inderdaad beste gewoon op een redelijk lege maag pakken.
( 2/3 uur van te voren niets eten )Ik heb paar dagen terug een verse lading gekregen en die begint al heel snel op te komen ( 20 min /30 min ) en een goede 3 uur houd het zeker aan. Om het langer te rekken kan je gewoon alcohol erbij drinken en joints roken. Maar dit zou ik pas doen als je weet wat je van de 2cb kan verwachten en je van jezelf goed weet wat je aankan!
Beter niet onvoorbereid aan iets nieuws beginnen, zodat je weet dat alles goed gaat. Zo verpest je ook niet je kans op een heeeele leuke avond ( en toekomstige keren )
( 2/3 uur van te voren niets eten )Ik heb paar dagen terug een verse lading gekregen en die begint al heel snel op te komen ( 20 min /30 min ) en een goede 3 uur houd het zeker aan. Om het langer te rekken kan je gewoon alcohol erbij drinken en joints roken. Maar dit zou ik pas doen als je weet wat je van de 2cb kan verwachten en je van jezelf goed weet wat je aankan!
Beter niet onvoorbereid aan iets nieuws beginnen, zodat je weet dat alles goed gaat. Zo verpest je ook niet je kans op een heeeele leuke avond
( en toekomstige keren )
Hey Boriz ik heb je verhaal weleens ergens anders gelezen en het is inderdaad zo'n beetje het ergste wat er kan gebeuren
Wat ik me afvroeg; heb je het toen ook met andere drugs gecombineerd?
Die hele dag ben ik los gegaan op 'Dominator', in totaal 'slechts' 2 pilletjes gebruikt waarvan de laatste rond 16.00 (geloof ik). De 2c-b nam ik pas om 01.00. Zal evengoed wel invloed hebben gehad hoor..
Dan had je beter moeten lezen vantevoren, dan had je geweten dat als je het snuift het 3 tot 4 keer zo sterk is. Je hebt dus een dosis binnen gekregen die te vergelijken is met 120 tot 160 mg oraal.
Weet ik man, het was erg dom maar ik had gewoon totaal geen angst voor dit goedje na alleen maar positieve ervaringen (denk stuk of 30 voordat het gelijk goed mis ging)
In mijn ogen was het echt een funmiddeltje met extreem mooie visuals en zware body loads.(Het kon me niet visueel genoeg zeg maar en ik was altijd prima in staat de bodyload te 'sturen')
Het werd met deze enorme dosis echter een zwaar spirituele, psychedelische en entheogene ervaring waarin ik het idee had letterlijk een andere dimensie in getrokken te worden waar duivels en helhonden mij aanvielen en constant vlak voor me, uit een soort visuele stenen muur, verschenen.
Vooral die honden.. Ik hoorde overal die pootjes en gekwijl in mn oren enzo, zag telkens schimmen van een soort bloedhonden. Er liep ook een soort mega grote vent bij die een beetje beestachtig aandeed en het voelde alsof die honden van hem waren. Verder stierf het van de entiteiten. Nog nooit zo realistische mindfuck gehad en heel soms nog steeds last van in de nacht in mn bedje (BRRRRRR)
Voor mensen die dit interessant vinden en een volledig tripreport willen lezen (zoals ik hem vlak na de trip in mijn hoofd had zitten) moeten me maar een pb'tje sturen. Ik heb een weblog waarop ik mijn meest benoemenswaardige (lifechanging) trips heb bijgehouden.
Grtz
laatste aanpassing
tof spul..erg lang geleden...weet niemand waar ik die sjit kan krijge?
jawel
tof spul..erg lang geleden...weet niemand waar ik die sjit kan krijge?
Zoek en gij zult vinden
heb gister 10mg 2c-b geprobeerd en was toppie! maar na een tijdje buisje G erbij getikt en dat verklote het een beetje dus mijn mening is als je 2c-b doet combineer het niet met andere drugs, geniet dan alleen van het 2c-b gevoel.
heb gister 10mg 2c-b geprobeerd en was toppie! maar na een tijdje buisje G erbij getikt en dat verklote het een beetje dus mijn mening is als je 2c-b doet combineer het niet met andere drugs, geniet dan alleen van het 2c-b gevoel.
Over het algemeen kon ik de bodyload van 2c-b altijd sturen/manipuleren zodat ik zelf voor het grootste deel bepaalde hoe het in mijn lichaam aanvoelde ipv het middel zelf.
Dit ging ook mentaal op in lichte doseringen dus idd, als je bekend bent met 2c-b hoef je het niet te combineren om er een extra waarde aan toe te voegen.
2C-B is erg leuk spul, vooral voor de onervaren/beginnende tripper.. gewoon leuk voor een avondje spacen, en bij lichte dossisen kun je er ook prima mee feesten.. ook vet icm lachgas
enige nadeel vind ik de boyload, ook al kunnen sommigen die beter handlen dan anderen..
![[img width=1024 height=768 cacheid=000f21df002ac13c5b15cd201a022f66a4]http://i32.tinypic.com/28k4tn7.jpg[/img]](/images/cache/000f21df002ac13c5b15cd201a022f66a4 "Bron: http://i32.tinypic.com/28k4tn7.jpg")
enige nadeel vind ik de boyload, ook al kunnen sommigen die beter handlen dan anderen..
laatste aanpassing
met bodyload doel ik op de puur lichamelijk bij-effecten die zich bij 2C-B voornamelijk uiten in misselijkheid, koude rillingen en soms een wat drukkend/rusteloos gevoel.. Deze kunnen de trip even beinvloeden, maar op een gegeven moment wordt het vaak wel minder, of je besteed er geen aandacht meer aan..
laatste aanpassing
heb eindelijk wat weten te bemachtigen volgend weekend maar is voort eerst uit proberen
volgend weekend maar is voort eerst uit proberenlaatste aanpassing
Ik heb nog de tijd meegemaakt dat het legaal was. Ik kan me nog herinneren dat het 2 hele kleine witte pilltjes waren voor 5 gulden. Heel goedkoop
whooo heb gister klein beetje gehad, beetje op het oog denk ik ongeveer 15 mg ofzo was best aardig van het padje 
lache spul heb echt dikke schik gehad om nix enzo klein beetje visuals maar niet echt maar wel dik wous in de kop ideaal spul
lache spul heb echt dikke schik gehad om nix enzo klein beetje visuals maar niet echt maar wel dik wous in de kop ideaal spul Receptje nodig?
Veel plezier ermee!
2C-B synthesis without LAH
by Beaker
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Introduction
The following is a synthesis of 2C-B from 2,5-dimethoxybenzaldehyde that does not require the use of the slightly hazardous and/or difficult to obtain reagents normally associated with its synthesis, notably LAH, pressurized H2, and Br2. No doubt some clandestine chemists have been discouraged from attempting the synthesis of what is, IMHO, a pretty cool substance by the nature of these reagents and the lack of a clearly written procedure for an alternate route that does not use them. However, alternate routes do exist, and one of them is detailed below. Note that this route does require one additional step to acheive the nitrostyrene reduction than with the use of H2 or LAH, but that the yield is actually substantially higher than what others have reported with those reducing systems. Also, the bromination procedure is somewhat unrefined at present and does not result in the greatest of yields or the easiest of workups, so feel free to use the classical procedure if you want to make or buy your own bromine. As a final note, although this route will happily accomodate batch sizes of ~50g in 2L glassware, it does not scale anywhere near as well as catalytic hydrogenation, so if you're trying to go huge, it's probably not for you.
Procedure
Step 1: Condensation of 2,5-dimethoxybenzaldehyde with nitromethane
In a 500mL RBF equipped with a reflux condenser and a stir bar, place 100g 2,5-dimethoxybenzaldehyde, 15g ammonium acetate, and 250mL of nitromethane. Heat to a gentle reflux while magnetically stirring. Maintain reflux for ~45min, by which time the color of the solution should progress from clear/yellow to a deep reddish-black. Remove heat and carefully pour the hot rxn mixture into 1L of ice-cold 70% IPA. Allow the IPA/rxn mixture to stand for a while. You should now have a flask full of orange solids floating in red/black mother liquor. Vacuum-filter the solids and wash them with additional portions of ice-cold 70% IPA until the filtrate is no longer reddish. Thoroughly dry the collected orange solids by pulling air through the filter for a while and then under vaccum. It is very important that the nitrostyrene be completely dry before proceding to the next step.
Yield - 106.1g (84 of 2,5-dimethoxynitrostyrene
Purity - Single spot by TLC, NMR is clean
Step 2: Sodium borohydride reduction of 2,5-dimethoxynitrostyrene
Into a dry 2L RBF flask equipped with a stir bar was added 400mL of anhydrous ethanol (If you can't get anhydrous ethanol, use anhydrous IPA (Do not use methanol!!!). The rxn was cooled to 0°C in an ice/water bath and 36.2g of sodium borohydride was added (slight H2 evolution). A pressure-equalized addition funnel was charged with a pre-made saturated solution of 50g 2,5-dimethoxynitrostyrene in THF (about 600mL) and attached to the flask. A piece of tubing was attached to the top of the addition funnel and run outside to vent the hydrogen that is will evolve during the course of the reaction. While maintaining the ice/water bath, slowly (reaction is exothermic, so go slowly) all of the bright yellow nitrostyrene solution (refill the addition funnel if necessary) was added to the sodium borohydride solution over the course of ~90 min (Note: gas will evolve over the course of the addition. It is H2. Be careful). After the addition is complete, the rxn was allowed to stir for an additional 10 min and then poured into a 4L erlenmeyer containing 1L of H2O and a 3" stir bar (H2 evolution). While stirring, 250mL glacial acetic acid (Heavy H2 evolution) was carefully added (one could use 400 mL 31.45% HCl). The quenched reaction mixture was divided into three portions. In a 2L sep funnel, each portion was combined with 500mL Et2O (or toluene) and 500mL brine. The funnel was shaken and the aqueous (bottom) layer was discarded. The organics were washed with 3 additional 500mL portions of brine. This was repeated with the other two portions. The organics were combined, dried over MgSO4, filtered and the solvent evaporated to give a clear yellow oil.
Yield - 47.0g of crude 2,5-dimethoxynitroethane
Purity - Two spots by TLC. NMR analysis indicates a 50:1 molar ratio of the desired product to dimeric impurity (this is the only impurity present). Adjusted yield of 2,5-dimethoxynitroethane is 45.2g (89.5%).
Step 3: Catalytic Transfer Hydrogenation of Crude 2,5-dimethoxynitroethane
The crude product of the previous step was dissolved in 400mL MeOH and placed in a 1L RBF equipped with a stir bar. In a separate beaker away from all combustible materials, 1g of 10% Pd/C was carefully wetted down with MeOH and the resulting slurry transferred to the rxn flask. To the rxn flask was added 62g ammonium formate. The flask was equipped with a reflux condensor, a piece of tubing was attached to the top of the condensor, and the end of the tubing was submenged in a container of water (this works to exclude O2 from the rxn while allowing the evolving CO2 to escape). The rxn was gently refluxed for 24 h (CO2 evolution), cooled, filtered through celite to remove the Pd/C, and the solvent evaporated. The residue was taken up in 150 mL of Et2O (or toluene) and 300 mL of H2O and the pH adjusted to >12 with 20% NaOH. The mixture was transfered to a sep funnel, shaken, and separated. The aqueous layer was extracted with 2x100 mL portions of Et2O (or toluene). The combined organics were dried over MgSO4, filtered, and gassed with HCl (2C-H*HCl is partially soluble in DCM, so don't gas in that solvent). The resulting white crystalline solids were filtered, washed with Et2O, and allowed to air dry to give 2C-H Hydrochloride.
Yield - 43.8g (94 of 2C-H Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Step 4: Bromination of 2C-H Freebase
The 2C-H*HCl was dissolved in a 300 mL H20. The pH was adjusted to >12 with 20% NaOH and the aqueous layer was extracted with 4x100 mL DCM. The DCM was evaporated to give 2C-H freebase, which was dissolved in 500 mL of 3:1 AcOH/H2O. The rxn was cooled to 0C in an ice/water bath. 37.3g of 48% aq. HBr was added, followed immediately by 23.8g of 30% H2O2. The rxn was stirred for 6 hr, allowing the ice bath to melt. The majority of the AcOH was removed under vacuum and the nasty reddish-black rxn mixture was partitioned between 1L H20 and 500 mL EtOAc (EtOAc was found to be much better for dissolving the impurities in this rxn than Et2O or toluene. This is messy at first, but everything should go into solution after much agitation). The layers were separated and the aqueous extracted with an additional 500 mL EtOAc. The aqueous was basified to pH >12 with 20% NaOH and extracted with 3x200 mL portions of Et2O. The combined organics were washed with 400 mL brine, dried over MgSO4, filtered and gassed with HCl. The resulting tan crystalline solids were filtered and recrystalized from boiling 1:1 IPA/Toluene to give pure 2C-B*HCl as a white crystaline solid.
Yield - 34.0g (57 of 2C-B Hydrochloride
Purity - Single spot by TLC. NMR is clean.
Before some jackass reads this procedure and asks me why 4 equivalents of sodium borohydride is used for the reduction, here is a interesting little table for your reading pleasure.
Eq. NaBH4 Molar ratio of 2,5-dimethoxy-
phenylnitroethane to dimer
2.5 6.25 : 1
3.5 44 : 1
4.0 50 : 1
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Sunlight's Voice:
After several failures, we finally got an interesting success using Beaker's 2C-H synth. We post it due me and others had problems with it. The rxn was carried out exactly as Beaker posted, no problems, everything goes fine. We made the sulfate salt instead of the hydrochloride by adding a 1:10 H2SO4:IPA v/v to the toluene extracts until the pH was slightly acidic. Yield was 65% from the nitrostyrene, not the >80% of Beaker, but anyway really interesting. By the way, we have never got a 84% of the nitro in step one, only 65-75% and reacting 2.5 hours, not 45 minutes, at 45 minutes the rxn seemed to be incomplete.
The reason of the success is the catalyst, all attempts with homemade catalyst gave miniscule yields, so we decided to buy it from Aldrich, 10% Pd/C on activated carbon, and now rxn finally works. In the reduction with Pd/C and ammonium formate, solid crystals are formed in the condenser (we guess they are ammonium carbonate) and they can clog the condenser. We had a little hazard in a previous test, so you need to control it and remove the crystals. We doubled the catalyst in order to finish rxn in 12 hours instead of 24, but rxn finish in about 5 hours, but we let it 12 hours. Other thing, the catalyst was washed with methanol, and when it was drying, it catched fire, next time we'll make a final wash with water before letting it dry, so we could reuse it.
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Barium's Voice:
For better yields:
10g (47,4mmol) 1-(2,5-dimethoxyphenyl)-2-nitroethane was dissolved in 50ml EtOH containing 300mg 5% Pd/C in a 250ml rb flask. 14g (166mmol) potassium formate was dissolved in 9ml water (500mmol, roughly 3 eq) and this solution was added to the alcohol solution in one portion. The mixture was heated to 70-75deg C for 5 hours with good stirring. During this time the mixture became thicker and thicker due to the precipitation of KHCO3. After three hours the mixture was too thick to be properly stirred so another 50ml EtOH was added. When 5 hours had passed the the reaction mixture was cooled to roomtemp and acidified to pH2 with dilute HCL , celite added and the catalyst removed by filtration. 100ml water was added to the filtrate and then it was extracted with 2x100ml toluene. The aqueous phase was the basified to pH 12 with 50% aq. NaOH and extracted with 2x100ml toluene. The organic phase was dried with MgSO4 and removed in a rotovap leaving a yellow oil. This oil was dissolved in 100ml EtOAc and gassed with dry HCL. Yield 6,6g (30,3mmol, 64 2,5-dimethoxyphenylethylamine HCl, mp 139-140°C.
In the presence of a catalyst hydrogen is formed according to: HCO2K + H2O __> H2 + KHCO3
For further reading check US patent 4,792,625
oooooooooooooohh dat moet lukken