mdma is niet ff 3 poedertjes bij mekaar gooien verwarmen en klaar hoor:
The most common synthetic routes for production of MDA, MDMA, MDE (MDEA),
and MDOH are from the precursor MDP-2-P. To get MDP-2-P first a natural
source of safrole is acquired. Safrole can be extracted from sassafras
oil, nutmeg oil, or several other sources which have been abundantly
documented in _Chemical Abstracts_ over the years. The safrole is
then easily isomerized into isosafrole when heated with NaOH or KOH. The
isosafrole is then oxidized into MDP-2-P. This latter procedure has been most
clearly presented in _Phenethylamines I Have Known and Loved_ by Alexander
Shulgin under synthesis #109 (MDMA). The synthesis of MDP-2-P from isosafrole
will require the use of a vacuum pump to evaporate the solvent from the
final product in vacuo. An aspirator will not, unfortunately, be sufficient.
Once the MDP-2-P is synthesized there are several synthetic routes which
can be taken:
1. Sodium Cyanoborohydride
2. Aluminum Amalgam
3. Sodium Borohydride
4. Raney Nickel Catalysis
5. Leukart Reaction via N-formyl-MDA
6. Leukart Reaction via N-methyl-N-formyl-MDA
The sodium cyanoborohydride method is probably the one most attractive to
clandestine chemists. From the Dal Cason reference:
"It requires no knowledge of chemistry, has a wide applicability, offers
little chance of failure, produces good yields, does not require expensive
chemical apparatus or glassware, and uses currently available (and easily
synthesized) precursors"
The aluminum amalgam synthesis is often used but has a slightly higher risk
of failure and is not as versatile. The Raney Ni synthesis is more dangerous
and requires special equipment to be done right (although this scheme is used
in a significant number of clandestine labs). The sodium borohydride
requires harsher conditions for the chemicals (ie. reflux) than sodium
cyanoborohydride or aluminum amalgam and produces lower yields. The
Leukart reaction is 2-step with lower yields and requires chemical apparatus.
There are also two synthetic methods which proceed directly from safrole
rather than through isosafrole. The first is the Ritter reaction which goes
through the intermediate N-acetyl-MDA. The Ritter reaction is time-consuming,
requires a degree of laboratory skill and produces poor yields. The other
method uses HBr to produce 3,4-methylenedioxyphenyl-2-bromopropane which is
then converted into MDA or MDMA. This scheme produces poor yields, and
Dal Cason referenced the australian journal _ANALOG_ where a hazard had
been documented. It is, however, attractive for its sheer simplicity. It
requires no specialized chem equipment or reagents at all.
Beta-nitroisosafrole is a less used precursor, but there is a large
literature on the synthesis and reduction of nitro alkenes. This synthetic
route isn't as popular due to the easier availability of precursors for
MDP-2-P, and it also results in MDA which must then be further processed
to give MDMA or any other N-alkyl homolog of MDA. There are numerous ways
to convert beta-nitroisosafrole to MDA: LiAlH4, AlH3, electrolytic, Na(Hg),
BH3 - THF / NaBH4, Raney Ni catalyst, Pd / BaSO4 catalyst, Zn (Hg).
Beta-nitroisosafrole, when used, is commonly synthesized from piperonal.
Beta-nitroisosafrole can also be used as a precursor for MDP-2-P, but this
is not commonly done.
There are other synthetic routes, such as the use of substituted
3,4-methylenedioxycinnamic acid or the construction of alkyenedioxy bridges
from dihydroxy compounds. These, however, are typically not used for a
variety of reasons (difficulty, multiple-step, special equipment, etc). It
is also possible to synthesize N-alkyl derivatives of MDA from MDA (e.g.
synthesizing MDMA from MDA) but this is not commonly done in clandestine labs.
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als je hier nix van begrijpt, kan je maar beter wiet gaan verbouwen, das een stukkie makkelijker
