DISCLAIMER: Uiteraard niet voor commerciële doeleinde maar enkel voor 'academisch' onderzoek/gebruik
Sodium GHB
Procedure:
Dissolve 130 grams (3.25 moles) of pure sodium hydroxide in 400ml of tap water in a 1000ml glass container while stirring with a glass rod or similar. The dissolution is exothermic, and the solution will heat up. When everything has dissolved to form a clear solution, slowly add 250ml (280 g, 3.25 moles) of gamma-butyrolactone in 50 ml portions with good stirring. The addition of gamma-butyrolactone to the sodium hydroxide solution is also exothermic, and if it is added too fast the solution will begin to boil, and we don't want that. Keep track of the temperature with an immersed thermometer. The addition of the gamma-butyrolactone will take somewhere between 20-30 minutes. When everything has been added, let the mixture react for an additional 10 minutes with occasional stirring.
Now it is time to see if the reaction has gone to completion by checking the pH with universal pH paper. We are aiming for a pH of 7-8. If it is too high (pH >

, then add 10 ml of gamma-butyrolactone and let react for a few minutes more. If the pH is too low (pH < 7), add a few ml of concentrated NaOH solution. Continue like this until the pH level is within the desired limits.
The solution is perfectly clear and tastes slightly salty. It may be slightly yellow colored, but not much if pure enough butyrolactone was used (distillation of the lactone before use takes care of this problem). If an acid is used to neutralize a too basic a solution (instead of adding more lactone), crystals of the sodium salt of the acid can precipitate in the solution, and the taste is severely impaired. The final solution will be around 750 mL 50% NaGHB. The solution can be concentrated (by boiling off excess water) to ~600mL without it crystallizing at room temp, but if concentrating as far as to ~500 mL it will invariably solidify.
Het is trouwens dom aan chemie te beginnen zonder er kennis over het hebben, procedures zijn vaak niet zonder risico's, ook die van GHB.
Organic chemistry is for people who likes to cook!