Gejat van BL, maar voor de mensen die de Engelse taal beheersen en wel eens wat mdma wegwerken is dit zeer handig en makkelijk uiteglegd
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GreetX Chris
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Metaphorically, think of your brain as the engine of a car. Certain substances floor the gas pedal and make the car go faster than normal. This is fun. But in driving faster, you use up gas [serotonin, in this specific situation] faster as well. When these substances wear off, you are obviously left with less gas than you would have if you didn't do the speed-racer thing. With less gas, you can't drive as fast as you normally do. Therefore you operate less efficiently.
Low levels of serotonin can be characterized by changes in eating patterns, sleeping patterns, short term memory and the appearance of depressive symptoms. MDMA produces its loved up, empathic effect by increasing levels of serotonin. If the body's "gas" [serotonin] is used up faster than it is replaced, then one is left with less serotonin when it is all said and done... ...unless you go to a gas station and refill the tank [supplement with 5-HTP, eat foods rich in the amino acid trytophan like bananas or turkey meat]... ...or put the car in economy mode to use the gas more efficiently [use of an SSRI type anti-depressant]...
...or don't drive as fast, as often [use moderation in usage / frequency]. Because this is purely mathematical it applies to everyone regardless of their prior condition. It should however be noted that the lower levels of serotonin are not permanent [i.e. the size of your gas tank has not been reduced], but rather there is temporarily less gas in the tank than normally. Damage may even occur to the engine if driven hard with no gas in the tank.
Depletion of serotonin stores is one step in a proposed mechanism for the neurotoxicity of MDMA. It can be theoretically counteracted by using engine oil [antioxidants such as Vitamin C]. I must however warn that studies correlating MDMA with neurotoxicity have only been performed in animals and only using ridiculously high dosages / frequency of usage. There are ways in which one can decrease the negative side effects of MDMA and increase the positive ones. Although no studies have been done on these techniques and MDMA specifically, extrapolating biochemical facts and observing the experiences of those who have done it support their practice.
These practices are called preloading and postloading. The entire concept behind preloading and postloading is, extending the above metaphor, adding gas to the tank that MDMA is going to use up. Serotonin as aforementioned is responsible for the empathic, loved-up feelings from MDMA. Adding more serotonin to your system enhances these effects. More importantly, it hypothetically counteracts the mechanism MDMA is thought to induce neurotoxicity with.
5-hydroxytrytophan is the direct precursor of serotonin in the body. It is sold in health food stores to help people with sleeping disorders [one of serotonin's roles is in the regulation of sleep, as aforementioned]. It is not a drug, it is an amino acid with a hydroxyl molecule appended to it. Supplementation with 5-hydroxytrytophan enhances the loved-up, empathic feelings and cleans up the comedown. Hard come downs are usually generated by depletion of intraneuronal serotonin stores. The result of lessed serotonin stores, as mentioned above, are characterized by disruptions in normal sleeping and eating patterns, difficulty in verbal processing and committing facts to short term memory, as well as irritatiblity.
Most notably the impact of low serotonin levels is characterized by depression. Supplementation with 5-hydroxtrytophan [5-HTP for short] counteracts these negative side effects by putting more gas in the tank and ensuring that you don't run out. In animal studies, it is hypothesized that neurotoxicity from MDMA is due to the following process. I'll put it in layman's terms.
1] MDMA amps up serotonin and dopamine use.
2] Serotonin runs out
3] Dopamine goes where serotonin normally would
4] Altered dopamine molecules cause damage to nerves
Therefore by preventing the depletion of serotonin you minimize the amount of oxidized dopamine radicals that feed into pre-axonic serotonin terminals and cause axonic trimming. One of magnesium's major roles in the body is in muscle relaxation. It is the antagonist [opposite] of calcium, which helps to induce muscle contraction. The jaw clenching observed on MDMA can be minimized through magnesium supplementation. Added magnesium can also minimizing cramping due to dehydration.
Vitamin C is a potent antioxidant. As aforementioned it is thought that MDMA is neurotoxic due to oxidized free radicals. As such Vitamin C counteracts these free radicals and helps to minimize damage incurred. The aforementioned three elements are the most PROTECTIVE elements to a preloading regimen. The following elements are optional because they enhance the experience rather than protect you from anything specific.
L-Tyrosine is to dopamine what 5-HTP is to serotonin. It is its precursor. Dopamine provides the rushy, body buzz, speedy effects...increasing L-tyrosine levels enhances these sensations.
DLPA amongst other functions, helps to prolong the duration of action of pleasure inducing neurochemicals.
L-Glutamine is a precursor to neurotransmitters in the brain. It also imparts a protective effect on the brain but not as heavily as 5-HTP or Vitamin C.
Any substances that you are preloading with need to cross the blood brain barrier to be effective. Amino acids compete with each other to cross the blood brain barrier, hence eating foods rich with protein lessen the effects of the amino acids because so many are in competition. It's like having a race with 2 people or 1000 people. Those one of those two people are more likely to win when they're only racing against themselves. As such preloads are taken on a relatively empty stomach, 1-1.5 hours prior to rolling. Preferably they are taken with a sugary juice to help the amino acids cross the blood brain barrier. Grapefruit juice inhibits one of the p450 cytochrome C digestive enzymes in the digestive tract that metabolizes MDMA and hence can make the effects of the drug somewhat more effective. It should be noted that preloading can upset some people's stomachs or cause diarrhea due to the acidity of the stomach. In which case these symptoms are easily counteracted by the following steps:
1] Mix the capped substances into juice, shake thoroughly, and sip the solution slowly over the course of an hour prior to a roll.
2] Immodium can counteract the diarrhea and does not interfere with a roll.
3] Tums or any calcium carbonate based antacid reduces the acidity of the stomach and counteracts the feelings of sickness one might encounter when coming up from a roll or after preloading.
A newbie I came across on the weekend was doubled over from their pill hitting them too hard - two tums and ten minutes later they were up on their feet feeling fine. If necessary you can also eat a non-acidic carbohydrate based food to buffer acidity, such as bread, muffins, etc.
The practice of postloading is metaphorically to fill up the tank after a long, fast ride. You restore the elements depleted by MDMA, and in doing so, bypass negative side effects and clean up your comedown while restoring normal function.
The only elements required in a postloading regimen are the protective ones. It is suggested that one employ 5-HTP, Vitamin C, Magnesium for the aforementioned reasons. A multivitamin is beneficial to help replace spent micronutrients. Water is of course beneficial. L-Tyrosine, DLPA are not desired nor necessary. You will know if you are bypassing the negative side effects of serotonin depletion if you can sleep soundly after rolling, and do not experience significant post-MDMA depression or disturbances in verbal processing, short term memory and eating patterns. Natural sources of trytophan [the precursor to 5-hydroxtrytophan, two steps away from serotonin] include bananas and turkey meat.
Turkey's high level of trytophan is the reason why most people feel sleepy after thanksgiving / christmas dinners - the high concentration of trytophan converts to serotonin in the bloodstream. Because of serotonin's relationship to the regulation of sleep, fatigue is induced. In so far as exact dosages of these elements, it should be noted that it varies from person to person and experimentation is key. The following are guidelines that have been found to work for many. It should also be noted that changing the ratio's of elements can provide different effects. I.E. Decreasing 5-HTP and increasing L-Tyrosine/DLPA can enhance the speediness of a pill, but would not protect the brain from neurotoxic effects as much as more 5-HTP would. Excessive 5-HTP can mellow out a roll. Not make it mashy, but reduce the speediness of the pill.
Preloading:
1. 5-HTP - 200-400mg
2. L-Tyrosine - 500-1500mg
3. DLPA - 500-1500mg
4. L-Glutamine - 2-5 grams
5. Magnesium - 500-1000mg
Post load:
1. 5-HTP - 200-400mg
2. Vitamin C - 1000mg+
3. Magnesium - 500-1000mg
Remember to experiment and take these things slowly as the sheer volume of pills ingested can upset the stomach. All elements are legal and can be found readily in health food stores and at online health food retailers. It may seem expensive to buy all these things but to protect your brain against neurotoxic effects and reduce other negative side effects it is well worth it. SSRI type antidepressants have been shown to impart a neuroprotective effect after a roll as well. Specifically fluoxetine [Prozac] has been shown to prevent neurotoxic effects in animals.
People have very rarely wanted to go back to rolling without preloading / postloading once they tried it. I just hope that this helps makes things safer for people out there. You have to believe that you have control over what happens to you and that you don't have to get screwed into anything.
Low levels of serotonin can be characterized by changes in eating patterns, sleeping patterns, short term memory and the appearance of depressive symptoms. MDMA produces its loved up, empathic effect by increasing levels of serotonin. If the body's "gas" [serotonin] is used up faster than it is replaced, then one is left with less serotonin when it is all said and done... ...unless you go to a gas station and refill the tank [supplement with 5-HTP, eat foods rich in the amino acid trytophan like bananas or turkey meat]... ...or put the car in economy mode to use the gas more efficiently [use of an SSRI type anti-depressant]...
...or don't drive as fast, as often [use moderation in usage / frequency]. Because this is purely mathematical it applies to everyone regardless of their prior condition. It should however be noted that the lower levels of serotonin are not permanent [i.e. the size of your gas tank has not been reduced], but rather there is temporarily less gas in the tank than normally. Damage may even occur to the engine if driven hard with no gas in the tank.
Depletion of serotonin stores is one step in a proposed mechanism for the neurotoxicity of MDMA. It can be theoretically counteracted by using engine oil [antioxidants such as Vitamin C]. I must however warn that studies correlating MDMA with neurotoxicity have only been performed in animals and only using ridiculously high dosages / frequency of usage. There are ways in which one can decrease the negative side effects of MDMA and increase the positive ones. Although no studies have been done on these techniques and MDMA specifically, extrapolating biochemical facts and observing the experiences of those who have done it support their practice.
These practices are called preloading and postloading. The entire concept behind preloading and postloading is, extending the above metaphor, adding gas to the tank that MDMA is going to use up. Serotonin as aforementioned is responsible for the empathic, loved-up feelings from MDMA. Adding more serotonin to your system enhances these effects. More importantly, it hypothetically counteracts the mechanism MDMA is thought to induce neurotoxicity with.
5-hydroxytrytophan is the direct precursor of serotonin in the body. It is sold in health food stores to help people with sleeping disorders [one of serotonin's roles is in the regulation of sleep, as aforementioned]. It is not a drug, it is an amino acid with a hydroxyl molecule appended to it. Supplementation with 5-hydroxytrytophan enhances the loved-up, empathic feelings and cleans up the comedown. Hard come downs are usually generated by depletion of intraneuronal serotonin stores. The result of lessed serotonin stores, as mentioned above, are characterized by disruptions in normal sleeping and eating patterns, difficulty in verbal processing and committing facts to short term memory, as well as irritatiblity.
Most notably the impact of low serotonin levels is characterized by depression. Supplementation with 5-hydroxtrytophan [5-HTP for short] counteracts these negative side effects by putting more gas in the tank and ensuring that you don't run out. In animal studies, it is hypothesized that neurotoxicity from MDMA is due to the following process. I'll put it in layman's terms.
1] MDMA amps up serotonin and dopamine use.
2] Serotonin runs out
3] Dopamine goes where serotonin normally would
4] Altered dopamine molecules cause damage to nerves
Therefore by preventing the depletion of serotonin you minimize the amount of oxidized dopamine radicals that feed into pre-axonic serotonin terminals and cause axonic trimming. One of magnesium's major roles in the body is in muscle relaxation. It is the antagonist [opposite] of calcium, which helps to induce muscle contraction. The jaw clenching observed on MDMA can be minimized through magnesium supplementation. Added magnesium can also minimizing cramping due to dehydration.
Vitamin C is a potent antioxidant. As aforementioned it is thought that MDMA is neurotoxic due to oxidized free radicals. As such Vitamin C counteracts these free radicals and helps to minimize damage incurred. The aforementioned three elements are the most PROTECTIVE elements to a preloading regimen. The following elements are optional because they enhance the experience rather than protect you from anything specific.
L-Tyrosine is to dopamine what 5-HTP is to serotonin. It is its precursor. Dopamine provides the rushy, body buzz, speedy effects...increasing L-tyrosine levels enhances these sensations.
DLPA amongst other functions, helps to prolong the duration of action of pleasure inducing neurochemicals.
L-Glutamine is a precursor to neurotransmitters in the brain. It also imparts a protective effect on the brain but not as heavily as 5-HTP or Vitamin C.
Any substances that you are preloading with need to cross the blood brain barrier to be effective. Amino acids compete with each other to cross the blood brain barrier, hence eating foods rich with protein lessen the effects of the amino acids because so many are in competition. It's like having a race with 2 people or 1000 people. Those one of those two people are more likely to win when they're only racing against themselves. As such preloads are taken on a relatively empty stomach, 1-1.5 hours prior to rolling. Preferably they are taken with a sugary juice to help the amino acids cross the blood brain barrier. Grapefruit juice inhibits one of the p450 cytochrome C digestive enzymes in the digestive tract that metabolizes MDMA and hence can make the effects of the drug somewhat more effective. It should be noted that preloading can upset some people's stomachs or cause diarrhea due to the acidity of the stomach. In which case these symptoms are easily counteracted by the following steps:
1] Mix the capped substances into juice, shake thoroughly, and sip the solution slowly over the course of an hour prior to a roll.
2] Immodium can counteract the diarrhea and does not interfere with a roll.
3] Tums or any calcium carbonate based antacid reduces the acidity of the stomach and counteracts the feelings of sickness one might encounter when coming up from a roll or after preloading.
A newbie I came across on the weekend was doubled over from their pill hitting them too hard - two tums and ten minutes later they were up on their feet feeling fine. If necessary you can also eat a non-acidic carbohydrate based food to buffer acidity, such as bread, muffins, etc.
The practice of postloading is metaphorically to fill up the tank after a long, fast ride. You restore the elements depleted by MDMA, and in doing so, bypass negative side effects and clean up your comedown while restoring normal function.
The only elements required in a postloading regimen are the protective ones. It is suggested that one employ 5-HTP, Vitamin C, Magnesium for the aforementioned reasons. A multivitamin is beneficial to help replace spent micronutrients. Water is of course beneficial. L-Tyrosine, DLPA are not desired nor necessary. You will know if you are bypassing the negative side effects of serotonin depletion if you can sleep soundly after rolling, and do not experience significant post-MDMA depression or disturbances in verbal processing, short term memory and eating patterns. Natural sources of trytophan [the precursor to 5-hydroxtrytophan, two steps away from serotonin] include bananas and turkey meat.
Turkey's high level of trytophan is the reason why most people feel sleepy after thanksgiving / christmas dinners - the high concentration of trytophan converts to serotonin in the bloodstream. Because of serotonin's relationship to the regulation of sleep, fatigue is induced. In so far as exact dosages of these elements, it should be noted that it varies from person to person and experimentation is key. The following are guidelines that have been found to work for many. It should also be noted that changing the ratio's of elements can provide different effects. I.E. Decreasing 5-HTP and increasing L-Tyrosine/DLPA can enhance the speediness of a pill, but would not protect the brain from neurotoxic effects as much as more 5-HTP would. Excessive 5-HTP can mellow out a roll. Not make it mashy, but reduce the speediness of the pill.
Preloading:
1. 5-HTP - 200-400mg
2. L-Tyrosine - 500-1500mg
3. DLPA - 500-1500mg
4. L-Glutamine - 2-5 grams
5. Magnesium - 500-1000mg
Post load:
1. 5-HTP - 200-400mg
2. Vitamin C - 1000mg+
3. Magnesium - 500-1000mg
Remember to experiment and take these things slowly as the sheer volume of pills ingested can upset the stomach. All elements are legal and can be found readily in health food stores and at online health food retailers. It may seem expensive to buy all these things but to protect your brain against neurotoxic effects and reduce other negative side effects it is well worth it. SSRI type antidepressants have been shown to impart a neuroprotective effect after a roll as well. Specifically fluoxetine [Prozac] has been shown to prevent neurotoxic effects in animals.
People have very rarely wanted to go back to rolling without preloading / postloading once they tried it. I just hope that this helps makes things safer for people out there. You have to believe that you have control over what happens to you and that you don't have to get screwed into anything.
______________________________________________________________
GreetX Chris
